子宫内膜增生.ppt

遗传因素遗传因素其它相关因素其它相关因素 雌孕激素受体雌孕激素受体 相关基因和蛋白：相关基因和蛋白：Bcl-2基因基因 PTEN基因基因 PCNA(增殖细胞核抗原增殖细胞核抗原)This is the microscopic appearance of normal proliferative endometrium in the menstrual cycle.The proliferative phase is the variable part of the cycle.In this phase,tubular glands with columnar cells and surrounding dense stroma are proliferating to build up the endometrium following shedding with previous menstruation.Here is early secretory endometrium.The appearance with prominent subnuclear vacuoles in cells forming the glands is consistent with post-ovulatory day 2.The histologic changes following ovulation are quite constant over the 14 days to menstruation and can be utilized to date the endometrium.正常子宫内膜正常子宫内膜 增生期增生期 早期分泌期早期分泌期(proliferative endometrium)(early secretory endometrium)This is normal secretory phase endometrium.Note the larger tortuous glands with secretions.The secretory phase follows a set 14 day course leading to either implantation of a fertilized ovum or menstruation.晚期分泌期（月经前期）晚期分泌期（月经前期）(secretory phase endometrium)腺上皮细胞非典型增生腺上皮细胞非典型增生腺体结构单纯性增生腺体结构单纯性增生腺上皮细胞非典型增生腺上皮细胞非典型增生腺体结构复杂性增生腺体结构复杂性增生