血药浓度监测回顾性分析硕士学位论文.doc

学位论文Shandong University Master,s Thesis硕 士 学 位 论 文论文20062009年血药浓度监测回顾性分析Retrospectively analysis of blood concentration monitoring of Qilu hospital of Shandong university between 2006 and 2009目 录中文摘要1英文摘要3符号说明6前言7第一部分 四种抗癫痫药物血药浓度监测结果回顾分析1 仪器与试剂92 方法92.1 采集血样92.2 测定方法92.3 血药浓度判断标准93 结果93.1 2006-2009年4种抗癫痫药物各年度血药浓度监测结果103.1.1 2006年4种抗癫痫药物血药浓度监测结果103.1.2 2007年4种抗癫痫药物血药浓度监测结果123.1.3 2008年4种抗癫痫药物血药浓度监测结果143.1.4 2009年4种抗癫痫药物血药浓度监测结果163.2 2006-2009年4种抗癫痫药物各年度汇总分析183.2.1 2006年4种抗癫痫药物监测汇总分析183.2.2 2007年4种抗癫痫药物监测汇总分析193.2.3 2008年4种抗癫痫药物监测汇总分析203.2.4 2009年4种抗癫痫药物监测汇总分析213.3 2006-2009年4种抗癫痫药物监测分析 223.3.1 2006-2009年丙戊酸钠血药浓度测定结果分析 223.3.2 2006-2009年卡马西平血药浓度测定结果分析 233.3.3 2006-2009年苯巴比妥血药浓度测定结果分析 243.3.4 2006-2009年苯妥英钠血药浓度测定结果分析 253.4 2006-2009年4种抗癫痫药物监测人次、年龄和性别汇总分析263.4.1 2006-2009年4种抗癫痫药物监测人次所占比例 263.4.2 2006-2009年4种抗癫痫药物应用患者年龄汇总分析 273.4.3 2006-2009年4种抗癫痫药物在有效浓度范围内男女所占比例汇总分析 283.4.4 2006-2009年4种抗癫痫药物低于浓度范围男女所占比例汇总分析 303.4.5 2006-2009年4种抗癫痫药物高于浓度范围男女所占比例汇总分析 313.5 2006-2009年4种抗癫痫药物测定次数分布情况 334讨论 34第二部分 环孢素血药浓度监测结果回顾分析1 仪器与试剂 362 方法 362.1采集血样 362.2测定方法 362.3血药浓度判断标准 363 结果363.1 20062009年各年度环孢素血药浓度监测分析 373.2 20062009年四年内环孢素血液浓度监测汇总分析 383.3 年龄与环孢素血药浓度监测汇总分析 403.4 不同性别与环孢素血药浓度监测汇总分析 413.5 环孢素监测次数汇总分析 434 讨论 44全文结论45参考文献48致 谢51攻读学位论文期间发表的学术论文52LISTChinese abstract1English abstract3Abbreviations6Introduction7The first part Retrospective analysis of blood concentration monitoring of 4 kind anti-epileptic drugs1 Instruments and reagents92 Methods92.1 Blood sampling92.2 Method for determination92.3 Judgment standard of blood drug concentration93 Results93.1 The results of blood concentration monitoring of 4 kind anti-epileptic drugs in each year from 2006 to 2009103.1.1 The results of blood concentration monitoring of 4 kind anti-epileptic drugs in 2006103.1.2 The results of blood concentration monitoring of 4 kind anti-epileptic drugs in 2007123.1.3 The results of blood concentration monitoring of 4 kind anti-epileptic drugs in 2008143.1.4 The results of blood concentration monitoring of 4 kind anti-epileptic drugs in 2009163.2 Summary analysis of 4 kind anti-epileptic drugs in each year from 2006 to 2009183.2.1 Summary analysis of 4 kind anti-epileptic drugs in 2006183.2.2 Summary analysis of 4 kind anti-epileptic drugs in 2007193.2.3 Summary analysis of 4 kind anti-epileptic drugs in 2008203.2.4 Summary analysis of 4 kind anti-epileptic drugs in 2009213.3 Analysis of blood concentration monitoring of 4 kind anti-epileptic drugs from 2006 to 2009223.3.1 Analysis of blood concentration monitoring of valproic acid sodium from 2006 to 2009223.3.2 Analysis of blood concentration monitoring of carbamazepine from 2006 to 2009233.3.3 Analysis of blood concentration monitoring of phenobarbital from 2006 to 2009243.3.4 Analysis of blood concentration monitoring of phenytoin sodium from 2006 to 2009253.4 Summary analysis of monitoring person-time, age and sex of 4 kind anti-epileptic drugs from 2006 to 2009263.4.1 The ratio of monitoring person-time of 4 kind anti-epileptic drugs from 2006 to 2009263.4.2 The summary analysis of age using 4 kind anti-epileptic drugs from 2006 to 2009273.4.3 The ratio of male and female in effective concentration range of 4 kind anti-epileptic drugs from 2006 to 2009283.4.4 The ratio of male and female lower than effective concentration range of 4 kind anti-epileptic drugs from 2006 to 2009303.4.5 The ratio of male and female more tha